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This Special Issue of Cancers focuses on new advances in the treatment of renal cell carcinoma, both surgical and pharmacological (and combinations of these), and novel approaches to tackle treatment resistance and improve our understanding of this phenomenon.

renal cell carcinoma --- autophagy --- hydroxychloroquine --- chloroquine --- ROC-325 --- cysteine cathepsins --- cysteine cathepsin inhibitors --- lysosome --- renal cancer --- metastatic renal cell carcinoma --- immune-based combination therapies --- network meta-analysis --- PD-L1 --- predictive --- biomarker --- treatment --- TKIs --- mRCC --- biomarkers --- soluble factors --- immunotherapy --- renal cell carcinoma (RCC) --- sunitib resistance --- artesunate (ART) --- Traditional Chinese Medicine (TCM) --- growth inhibition --- ferroptosis --- reactive oxygen species (ROS) --- clear cell renal cell carcinoma --- ccRCC --- RCC --- kidney cancer --- evolution --- evolutionary trajectory --- metastatic --- second line therapy --- renal cell cancer --- immune checkpoint inhibitors --- tyrosine kinase inhibitors --- individualization --- genomic signature --- transcriptomic analysis

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"Emiel Lamberts (1941), professor emeritus of contemporary history at KU Leuven, is an international expert in the political and religious history of Europe in the 19th and 20th centuries. His work and the central themes in his research are the starting point in World Views and Worldly Wisdom. No less than eighteen leading international researchers put different aspects of his work in the spotlight. A recurring theme, however, is the attraction and repulsion between the Roman Catholic Church and modernity in Europe between 1750 and 2000. The ambivalent relationship with modernity is therefore the leitmotiv of the first part of this volume, whereas the second part focuses on the repositioning of the Church and the tensions between religion, ideology and politics. In this way the volume reflects Lamberts's fascination for the history of political institutions as well as his research on Christian democracy. The contributions address--in a comparative way and from a transatlantic viewpoint--this broad period of time in history, which gave rise to different social movements and different models of society in Belgium and elsewhere."--Page 4 of cover.

Katholische Kirche --- Europe. --- Katolikus Egyház --- RCC --- Katoličeskaj Cerkovʹ --- Katoličke Cerkve --- Katolska Cyrkej --- Katolske Kirke --- Ecclesia Catholica --- Igreja Católica --- Römisch-Katholische Kirche --- Katholikē Ekklēsia --- Catholic Church --- Roman Catholic Church --- Eglise Catholique --- Eglise Catholique Romaine --- Chiesa Cattolica --- Katholieke Kerk --- Iglesia Católica --- Katolické Církve --- Kościoł Katolicki --- Katoličke Crkve --- Eglise catholique romaine --- Chiesa cattolica romana --- Roman catholic Church --- Eglise catholique --- Römische Kirche --- Kirche --- Katholizismus --- Unierte Ostkirchen --- Council of Europe countries --- Eastern Hemisphere --- Eurasia

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MicroRNAs (miRs) are small noncoding RNAs that function as post-transcriptional regulators of gene expression and have important roles in almost all biological pathways. Deregulated miR expression has been detected in numerous cancers, where miRs act as both oncogene and tumor suppressors. Due to their important roles in tumorigenesis, miRs have been investigated as prognostic and diagnostic biomarkers and as useful targets for therapeutic intervention. From a therapeutic point of view, two modalities can serve to rectify gene networks in cancer cells. For oncomiRs, a rational means is downregulation through antagomirs. Moreover, observations of the pathological reductions in tumor-suppressive miRs have inspired the concept of “miR replacement therapy” to enhance the amount of these miRs, thereby restoring them to normal levels. However, the clinical applicability of miR-based therapies is severely limited by the lack of effective delivery systems. Therefore, to understand the role of this new class of regulators, we need to identify the mRNA targets regulated by individual miRs as well as to develop specific, efficient, and safe delivery systems for therapeutic miRs.

Breast cancer --- Hypoxia inducible factor 1-alpha (HIF-1α) --- MicroRNA (miRNA) --- miR526b --- miR655 --- Oxidative stress --- Migration --- Cyclooxygenase-2 (COX-2) --- Prostaglandin E2 receptor 4 (EP4) --- PI3K/Akt --- adipokines --- endometrial cancer --- estrogens --- hyperinsulinemia --- insulin --- insulin resistance --- insulin signaling --- insulin-like growth factors --- microRNA --- miRNA --- ovarian cancer --- survival --- prognostic factor --- serum LDH --- blood biomarker --- circulating microRNA --- plasma --- immunotherapy --- immune checkpoint inhibitors --- metastatic melanoma --- hepatocellular carcinoma --- metastasis --- exosome --- bioinformatics analysis --- renal cancer --- RCC --- ccRCC --- meta-analysis --- miRNAs --- normal B-cell development --- B-CLL --- miRNA-transcription factor network --- regulation --- biomarker --- therapy --- prognosis --- diagnosis --- progression --- prediction --- smoking --- non-small cell lung cancer --- methylation --- miR-584-5p --- YKT6 --- snoRNA --- 2′-O-methylation --- pseudouridylation --- malignant melanoma --- cancer stem cell --- stemness --- head and neck squamous cell carcinoma --- colon cancer --- cancer stem cells --- microRNAs --- deformability --- PARP --- replication stress --- targeted therapy --- breast cancer --- circulating biomarkers --- medulloblastoma --- brain tumour --- subgroups --- stem cells --- n/a --- 2'-O-methylation

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Cantors made unparalleled contributions to the way time was understood and history was remembered in the medieval Latin West. The men and women who held this office in cathedrals and monasteries wereresponsible for calculating the date of Easter and the feasts dependent on it, for formulating liturgical celebrations season by season, managing the library and preparing manuscripts and other sources necessary to sustain the liturgical framework of time, and promoting the cults of saints. Crucially, their duties also often included committing the past to writing, from simple annals and chronicles to more fulsome histories, necrologies, and cartularies, thereby ensuring that towns, churches, families, and individuals could be commemorated for generations to come.
The contributions hereseek to address the fundamental question of how the range of cantors' activities can help us to understand the many different ways in which the past was written and, in the liturgy, celebrated acrossthe middle ages. Cantors, as this volume makes clear, shaped the communal experience of the past in the Middle Ages; the essays are studies of constructions, both of the building blocks of time and ofthe people who made and performed them, in acts of ritual remembrance and in written records.

Contributors: Cara Aspesi, Alison I. Beach, Katie Ann-Marie Bugyis, Margot E. Fassler, David Ganz, James Grier, Paul Antony Hayward, A.B. Kraebel, Lori Kruckenberg, Rosamond McKitterick, Henry Parkes, Susan Rankin, C.C. Rozier, Sigbjoryn Olsen Sonnesyn, Teresa Webber, Lauren Whitnah,

Church history --- Church music --- Civilization, Medieval --- Pastoral music (Sacred) --- Religious music --- Sacred vocal music --- Devotional exercises --- Liturgics --- Music --- Music in churches --- Psalmody --- History and criticism --- Religious aspects --- Christianity --- Cantors (Church music) --- Chantres --- Eglise --- Musique d'église --- Civilisation médiévale --- Histoire --- Musique d'église --- Civilisation médiévale --- Church history -- Middle Ages --- Historiography --- Middle Ages --- Catholic Church --- History --- Katholische Kirche --- 500-1500 --- Church musicians --- Historical criticism --- Authorship --- Criticism --- Katolikus Egyház --- RCC --- Katoličeskaj Cerkovʹ --- Katoličke Cerkve --- Katolska Cyrkej --- Katolske Kirke --- Ecclesia Catholica --- Igreja Católica --- Römisch-Katholische Kirche --- Katholikē Ekklēsia --- Roman Catholic Church --- Eglise Catholique --- Eglise Catholique Romaine --- Chiesa Cattolica --- Katholieke Kerk --- Iglesia Católica --- Katolické Církve --- Kościoł Katolicki --- Katoličke Crkve --- Eglise catholique romaine --- Chiesa cattolica romana --- Roman catholic Church --- Eglise catholique --- Römische Kirche --- Kirche --- Katholizismus --- Unierte Ostkirchen --- Medieval Period --- Christian church history --- History of Europe --- anno 500-1499 --- Cantors. --- Catholic Church. --- Christianity. --- Church History. --- Church music. --- Divine Office. --- Historiography. --- Liturgy. --- Medieval Europe. --- Medieval Latin West. --- Middle Ages. --- Necrologies. --- Prayer. --- Religion. --- Ritual Remembrance. --- Sacred song. --- Saint.

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Nineteenth-century female congregation founders could achieve levels of autonomy, power and prestige that were beyond reach for most women of their time. With a subject hidden for a long time behind a curtain of modesty and mystery, this book recounts the fascinating but ambiguous life stories of four Belgian religious women. A close reading of their personal writings unveils their conflicted existence: ambitious, engaged and bold on the one hand, suffering and isolated on the other, they were both victims and promotors of a nineteenth-century ideal of female submission. As religious and social entrepreneurs these women played an influential role in the revival of the church and the development of education, health care and social provisions in modern Belgium. But, equally well, they were bound to rigid gender patterns and adherents of an ultramontane church ideology that fundamentally distrusted modern society.

C2 --- religieuzen --- vrouwen --- geloofsleven --- KADOC - Documentatie- en Onderzoekscentrum voor Religie, Cultuur en Samenleving (1977-) --- Religieuze instituten --- Christian religious orders --- Sociology of the family. Sociology of sexuality --- Autonomie. --- Frau. --- Geschlechterforschung. --- Ordensgründerin. --- Unterdrückung. --- Katholische Kirche. --- Belgien. --- Nuns --- Women in the Catholic Church --- Religieuses --- Femmes dans l'Eglise catholique --- History --- Histoire --- Feminist theology --- Theology, Feminist --- Theology, Doctrinal --- Sisters (in religious orders, congregations, etc.) --- Christians --- Monasticism and religious orders for women --- Women in the Catholic Church. --- Feminist theology. --- History. --- Kloosterleven--België--geschiedenis --- Vrouwen --- 245.4 --- Kloosterwezen--België--geschiedenis --- Vrouwen in de kerk --- Belgium --- Bäigien --- Baljīk --- Belchica --- Belçika --- Belçika Krallığı --- Beldjym --- Belezi --- Belga Királyság --- Beļgeja --- Belghia --- Belʹgi --- Bèlgia --- Belgia Kuningriik --- Bélgica --- Belgice --- Belgice Cynerīce --- Belgické královstv --- Belgi --- Belgien --- Bélgii Bikéyah --- Belgii͡ --- Belʹgii͡a Korollege --- Belgija --- Beļg̓ijas Karaliste --- Belgijos Karalyst --- Belgijsk --- Belgika --- Belgio --- Belgique --- Belgiska --- Belgiya --- Belgiyah --- Belgje --- Belgjiche --- Belgjo --- Belgujo --- Belʹhii͡ --- Belhika --- Bèljik --- Beljika --- Belʹjmudin Nutg --- Belsch --- Belsj --- Bélxica --- Berug --- Bheilg --- Bilgasuyu --- Bilhika Qhapaqsuyu --- Bilkiya --- Gwlad Belg --- Igihugu cyʼUbubirigi --- Karaleŭstva Belʹhii͡ --- Keuninkriek Belsj --- Kingdom of Belgium --- Kinigraich Bäigien --- Kinnekräich Belsch --- Kongeriget Belgien --- Königreich Belgien --- Königriich Belgie --- Koninkrijk Belgi --- Koninkrijk van Belgi --- Koninkryk van Belgi --- Kraljevina Belgija --- Kralojstwo Belgiskej --- Mamlakat Baljīk --- Mamlekhet Belgiyah --- Nsi ya ntotila ya Belezi --- Pelekiuma --- Pow Belg --- Reeriaght ny Belg --- Reĝlando Belgio --- Regne de Bèlgica --- Regno del Belgio --- Reino de Belchica --- Reino de Bélgica --- Reinu de Bélxica --- Ríocht na Beilge --- Rìoghachd na Beilge --- Royaume de Belgique --- Royômo de Bèlg·ique --- Ruwvaneth Belgek --- Teyrnas Gwlad Belg --- Ubelgiji --- Ububiligi --- Ububirigi --- Ufalme wa Ubelgiji --- Vasileio tou Velgiou --- Vãsilia di Belghia --- Velg --- Velgio --- Meeûs, Anna de, --- Kestre, Fanny, --- Cornet, Antoinette, --- Telghuys, Wilhelmina, --- Börngen, ... --- Katholische Kirche --- 1800-1899 --- Börngen, ... --- ... --- Düsseldorf --- Leser, Rosalie --- De Meeûs, Anna, --- Katolikus Egyház --- RCC --- Katoličeskaj Cerkovʹ --- Katoličke Cerkve --- Katolska Cyrkej --- Katolske Kirke --- Ecclesia Catholica --- Igreja Católica --- Römisch-Katholische Kirche --- Katholikē Ekklēsia --- Catholic Church --- Roman Catholic Church --- Eglise Catholique --- Eglise Catholique Romaine --- Chiesa Cattolica --- Katholieke Kerk --- Iglesia Católica --- Katolické Církve --- Kościoł Katolicki --- Katoličke Crkve --- Eglise catholique romaine --- Chiesa cattolica romana --- Roman catholic Church --- Eglise catholique --- Römische Kirche --- Kirche --- Katholizismus --- Unierte Ostkirchen